Melanotan II
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About Melanotan II
Melanotan II (MT-II) is a cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone that non-selectively activates multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R). Originally developed at the University of Arizona as a sunless tanning agent, Melanotan II has since become a widely studied multi-target research compound with a broad pharmacological profile. Its activation of MC1R drives melanogenesis — the production of eumelanin in melanocytes — studied as a photoprotective mechanism against UV-induced DNA damage. MC4R activation produces appetite suppression and has been investigated in obesity and energy homeostasis research, while the same receptor accounts for its extensively documented effects on arousal signalling in pre-clinical models. MC3R involvement contributes further to energy homeostasis signalling. Research applications span dermatology, metabolic syndrome, appetite pharmacology, and neuroscience. Due to its broad receptor profile and potent activity, Melanotan II requires careful dosing and professional oversight in all research protocols. Supplied at ≥99% HPLC purity.
Usage Guidelines
✓ Suitable For
- Useful for multi-receptor melanocortin pharmacology and comparative selectivity research
- Melanogenesis and photoprotection mechanism studies
- Appetite suppression and energy homeostasis models via MC3R/MC4R pathways
- Well-established pre-clinical literature — valuable reference compound
✗ Not Recommended For
- Requires careful professional supervision due to broad receptor activity profile
- Monitor for nausea and flushing common in initial administration phases of research protocols
- Not suitable for individuals with a history of melanoma or skin malignancies
- Not intended for unsupervised use — medical guidance strongly recommended before any protocol