Selank
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About Selank
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences as a stable analogue of tuftsin, an endogenous immunomodulatory tetrapeptide. Classified as an anxiolytic peptide nootropic, Selank has accumulated a substantial body of published literature on its anxiolytic, antidepressant, and cognitive-enhancing properties. Its primary mechanism involves modulation of the GABA-A receptor system — producing anxiolytic effects comparable to benzodiazepines in rodent models without the sedation, tolerance, or dependency liability associated with that drug class. Additionally, Selank enhances expression of BDNF (Brain-Derived Neurotrophic Factor), influences the stability of enkephalins, and modulates dopaminergic and serotonergic transmission, contributing to its nootropic and mood-stabilising profile. Studies have investigated Selank in generalised anxiety models, memory consolidation research, attention and focus paradigms, and immune-cognitive interaction studies. Its immunomodulatory properties derived from its tuftsin lineage have also been studied in the context of infection-related cognitive decline. Supplied at ≥99% HPLC purity.
Usage Guidelines
✓ Suitable For
- Ideal for non-sedating anxiolytic mechanism research and GABA-A modulation studies
- Suitable for BDNF upregulation memory consolidation and nootropic research
- Immune-cognitive interaction models benefit from Selank's tuftsin-derived properties
- Well tolerated in pre-clinical models — extensive research literature available
✗ Not Recommended For
- Not a replacement for prescribed anxiolytic medications — for research contexts only
- Consult a psychiatrist or neurologist before involvement in any protocol affecting anxiety or mood
- Not recommended for individuals with active psychiatric conditions outside supervised research
- Not intended for use without professional research or clinical oversight