Tesamorelin
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About Tesamorelin
Tesamorelin is a synthetic GHRH analogue comprising the full 44-amino acid GHRH sequence with a trans-3-hexenoic acid group at the N-terminus, which confers enhanced stability against dipeptidyl peptidase-IV (DPP-IV) degradation compared to native GHRH. This modification extends its effective half-life while preserving the physiological pulsatile GH secretion mechanism through intact pituitary GHRH receptor signalling. Tesamorelin received FDA approval in 2010 (as Egrifta) for the treatment of HIV-associated lipodystrophy — specifically reduction of excess visceral abdominal fat in HIV-positive patients — making it one of the few GHRH analogues with robust clinical validation. Research applications extend to visceral adiposity mechanisms in non-HIV populations, metabolic syndrome, IGF-1 axis regulation, cognitive function in age-related GH decline, and comparative pharmacology of GHRH analogues. Its proven efficacy in reducing visceral fat through physiological GH axis stimulation rather than exogenous GH administration makes it particularly valuable for studies requiring metabolic specificity without supraphysiological GH exposure. Supplied at ≥99% HPLC purity.
Usage Guidelines
✓ Suitable For
- FDA-approved mechanism provides exceptional translational research credibility
- Ideal for visceral adiposity metabolic syndrome and lipodystrophy mechanism research
- Preferred for GH axis studies requiring DPP-IV-stable GHRH with physiological pulsatility
- Valuable for IGF-1 axis regulation and age-related metabolic decline investigations
✗ Not Recommended For
- Not for use without medical supervision — GH axis compounds require endocrinological oversight
- Monitor IGF-1 levels in longer research protocols — supraphysiological elevation is a risk
- Not suitable for individuals with active malignancies given IGF-1's mitogenic potential
- Consult an endocrinologist or metabolic physician before beginning any Tesamorelin protocol